Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase-Producing Enterobacterales During a Regional Outbreak

Marco Falcone; Giusy Tiseo; Alberto Antonelli; Cesira Giordano; Vincenzo Di Pilato; Pietro Bertolucci; Eva Maria Parisio; Alessandro Leonildi; Noemi Aiezza; Ilaria Baccani; Enrico Tagliaferri; Lorenzo Righi; Silvia Forni; Spartaco Sani; Maria Teresa Mechi; Filippo Pieralli; Simona Barnini; Gian Maria Rossolini; Francesco Menichetti

doi:10.1093/ofid/ofaa011

Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase-Producing Enterobacterales During a Regional Outbreak

Open Forum Infect Dis. 2020 Jan 21;7(2):ofaa011. doi: 10.1093/ofid/ofaa011. eCollection 2020 Feb.

Authors

Marco Falcone¹, Giusy Tiseo¹, Alberto Antonelli², Cesira Giordano³, Vincenzo Di Pilato², Pietro Bertolucci⁴, Eva Maria Parisio⁵, Alessandro Leonildi⁴, Noemi Aiezza², Ilaria Baccani², Enrico Tagliaferri⁶, Lorenzo Righi⁷, Silvia Forni⁸, Spartaco Sani⁹, Maria Teresa Mechi⁷, Filippo Pieralli¹⁰, Simona Barnini³, Gian Maria Rossolini^{2

11}, Francesco Menichetti¹

Affiliations

¹ Infectious Disease Unit, Azienda Ospedaliera Universitaria Pisana, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
² Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
³ Microbiology Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.
⁴ Faculty of Medicine, University of Pisa, Pisa, Italy.
⁵ Operative Unit of Chemical-Clinical and Microbiological Analysis, San Luca Hospital, Lucca, Italy.
⁶ Infectious Diseases Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.
⁷ Quality of Care and Clinical Networks, Tuscany Region, Italy.
⁸ Agenzia Regionale di Sanità della Toscana, Florence, Italy.
⁹ Infectious Disease Unit, Livorno Hospital, Livorno, Italy.
¹⁰ Intermediate Care Unit, Florence Careggi University Hospital, Florence, Italy.
¹¹ Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy.

Abstract

Limited data about New Delhi metallo-β-lactamase (NDM) bacteremia are available. Blood isolates from 40 patients with NDM bacteremia were studied for antibiotic susceptibility and whole-genomic sequencing. NDM bacteremia has high 30-day mortality. In most cases, aztreonam-avibactam is active in vitro. Ceftazidime-avibactam plus aztreonam may represent a feasible therapeutic option.

Keywords: New Delhi metallo-β-lactamases; bacteremia; carbapenem-resistant.