Eccentric versus conventional cycle training to improve muscle strength in advanced COPD: A randomized clinical trial

Jean Bourbeau; Riany De Sousa Sena; Tanja Taivassalo; Ruddy Richard; Dennis Jensen; Jacinthe Baril; Danielle Soares Rocha Vieira; Hélène Perrault

doi:10.1016/j.resp.2020.103414

Eccentric versus conventional cycle training to improve muscle strength in advanced COPD: A randomized clinical trial

Respir Physiol Neurobiol. 2020 May:276:103414. doi: 10.1016/j.resp.2020.103414. Epub 2020 Feb 9.

Authors

Jean Bourbeau¹, Riany De Sousa Sena², Tanja Taivassalo³, Ruddy Richard⁴, Dennis Jensen⁵, Jacinthe Baril⁶, Danielle Soares Rocha Vieira⁷, Hélène Perrault⁸

Affiliations

¹ Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, Research Institute of the McGill University Health Centre, McGill University, Montréal, Québec, Canada. Electronic address: jean.bourbeau@mcgill.ca.
² Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, Research Institute of the McGill University Health Centre, McGill University, Montréal, Québec, Canada; Department of Physical Therapy, University of Fortaleza, Fortaleza, Brazil; Department of Physical Therapy, Federal University of Ceara, Fortaleza, Brazil.
³ Department of Kinesiology and Physical Education, McGill University, Montréal, Québec, Canada.
⁴ Department of Sport Medicine and Functional Explorations, University-Hospital (CHU), Hôpital G. Montpied, Clermont, Ferrand, France.
⁵ Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, Research Institute of the McGill University Health Centre, McGill University, Montréal, Québec, Canada; Department of Kinesiology and Physical Education, McGill University, Montréal, Québec, Canada.
⁶ Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, Research Institute of the McGill University Health Centre, McGill University, Montréal, Québec, Canada.
⁷ Physical Therapy Department, Federal University of Santa Catarina, Brazil.
⁸ Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, Research Institute of the McGill University Health Centre, McGill University, Montréal, Québec, Canada; Faculty of Health Sciences, University of Ottawa, Ottawa, Canada.

PMID: 32050099
DOI: 10.1016/j.resp.2020.103414

Abstract

Objectives: To compare eccentric (ECC) and conventional concentric (CON) cycle training on quadriceps muscle strength in advanced COPD. Secondary objective was to assess functional capacity.

Methods: A parallel-group, assessor-blind, randomized trial was conducted. Severe COPD patients were randomized to either an ECC (n = 13) or CON (n = 11) cycling program for 30-min, 3 times/week for 10 weeks. ECC group trained at ∼4-fold higher power than the CON group at similar relative heart rate intensity.

Results: Isometric and isokinetic quadriceps peak torque improved after ECC but not CON; between group difference was significant for isometric peak muscle force (p < 0.05). Peak cycling power and endurance time increased in both groups (p < 0.05). Dyspnea at peak cycling power improved only after ECC training (p < 0.05). Sensory intensity ratings of dyspnea and leg fatigue were significantly lower (p < 0.05) during ECC compared with CON at equivalent relative heart rate intensities.

Conclusions: ECC could be an effective alternative and/or adjunct modality to pulmonary rehabilitation in severely ventilatory limited COPD patients.

Keywords: COPD; Eccentric exercise; Exercise training; Muscle strength; Pulmonary rehabilitation.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Bicycling*
Dyspnea / physiopathology*
Exercise
Exercise Therapy / methods*
Fatigue / physiopathology*
Heart Rate
Humans
Male
Middle Aged
Muscle Strength*
Pulmonary Disease, Chronic Obstructive / physiopathology
Pulmonary Disease, Chronic Obstructive / rehabilitation*
Quadriceps Muscle