Association between mean arterial pressure and risk of type 2 diabetes mellitus: The Rural Chinese Cohort Study

Prim Care Diabetes. 2020 Oct;14(5):448-454. doi: 10.1016/j.pcd.2020.01.007. Epub 2020 Feb 15.

Abstract

Aims: Limited evidence is available on the association of mean arterial pressure and risk of type 2 diabetes mellitus (T2DM) among Chinese people. We aimed to investigate the association between MAP and risk of T2DM in rural Chinese adults.

Methods: We performed a cohort study of 12,284 eligible participants (4668 men and 7616 women) without T2DM at baseline. Cox proportional-hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of MAP with risk of T2DM. Restricted cubic spline models were used to evaluate the dose-response association between MAP and risk of T2DM.

Results: During a median of 6.01 years follow-up (73,403.52 person-years), T2DM developed in 847 participants (318 men and 529 women). In the multivariable-adjusted models, risk of T2DM was significantly higher for women with the third (90-100mmHg) and fourth MAP categories (≥100mmHg) than the first category (<80mmHg) after adjusting for confounders (HR=1.74 [95% CI 1.14-2.68] and 1.84 [1.20-2.83]). Restricted cubic spline analysis revealed increased risk of T2DM with increasing MAP for women.

Conclusion: High MAP was related to high incident T2DM among women in China.

Keywords: Cohort study; Mean arterial pressure; Type 2 diabetes mellitus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Arterial Pressure*
  • China / epidemiology
  • Diabetes Mellitus, Type 2 / diagnosis
  • Diabetes Mellitus, Type 2 / epidemiology*
  • Female
  • Humans
  • Hypertension / diagnosis
  • Hypertension / epidemiology*
  • Hypertension / physiopathology
  • Incidence
  • Male
  • Middle Aged
  • Risk Assessment
  • Risk Factors
  • Rural Health*
  • Sex Factors
  • Young Adult