IL-8 as a potential biomarker in Guillain-Barre Syndrome

Eur Cytokine Netw. 2019 Dec 1;30(4):130-134. doi: 10.1684/ecn.2019.0436.

Abstract

This pilot study was designed to compare the levels of interleukin-8 (IL-8), a pro-inflammatory chemokine, in the cerebrospinal fluid (CSF) of patients with Guillain-Barre syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), non-inflammatory polyneuropathy (PNP), and other non-inflammatory neurological diseases (functional syndrome or migraine). The results show elevated CSF IL-8 levels in GBS compared to the other groups (p < 0.05). IL-8 could be considered a potential biomarker to differentiate GBS from CIDP. This distinction could be relevant in terms of therapeutic decisions and functional prognosis.

Keywords: cerebrospinal fluid; chemokine; chronic inflammatory demyelinating polyneuropathy; cytokine; inflammation.

MeSH terms

  • Adult
  • Aged
  • Biomarkers / cerebrospinal fluid
  • Diagnosis, Differential
  • Female
  • Guillain-Barre Syndrome / cerebrospinal fluid
  • Guillain-Barre Syndrome / diagnosis*
  • Guillain-Barre Syndrome / immunology
  • Humans
  • Interleukin-8 / cerebrospinal fluid*
  • Interleukin-8 / immunology
  • Male
  • Middle Aged
  • Migraine Disorders / cerebrospinal fluid
  • Migraine Disorders / diagnosis*
  • Migraine Disorders / immunology
  • Pilot Projects
  • Polyneuropathies / cerebrospinal fluid
  • Polyneuropathies / diagnosis*
  • Polyneuropathies / immunology
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / cerebrospinal fluid
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / diagnosis*
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / immunology
  • Retrospective Studies
  • Tumor Necrosis Factor-alpha / cerebrospinal fluid
  • Tumor Necrosis Factor-alpha / immunology

Substances

  • Biomarkers
  • CXCL8 protein, human
  • Interleukin-8
  • Tumor Necrosis Factor-alpha