Abstract
This pilot study was designed to compare the levels of interleukin-8 (IL-8), a pro-inflammatory chemokine, in the cerebrospinal fluid (CSF) of patients with Guillain-Barre syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), non-inflammatory polyneuropathy (PNP), and other non-inflammatory neurological diseases (functional syndrome or migraine). The results show elevated CSF IL-8 levels in GBS compared to the other groups (p < 0.05). IL-8 could be considered a potential biomarker to differentiate GBS from CIDP. This distinction could be relevant in terms of therapeutic decisions and functional prognosis.
Keywords:
cerebrospinal fluid; chemokine; chronic inflammatory demyelinating polyneuropathy; cytokine; inflammation.
MeSH terms
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Adult
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Aged
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Biomarkers / cerebrospinal fluid
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Diagnosis, Differential
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Female
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Guillain-Barre Syndrome / cerebrospinal fluid
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Guillain-Barre Syndrome / diagnosis*
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Guillain-Barre Syndrome / immunology
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Humans
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Interleukin-8 / cerebrospinal fluid*
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Interleukin-8 / immunology
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Male
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Middle Aged
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Migraine Disorders / cerebrospinal fluid
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Migraine Disorders / diagnosis*
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Migraine Disorders / immunology
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Pilot Projects
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Polyneuropathies / cerebrospinal fluid
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Polyneuropathies / diagnosis*
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Polyneuropathies / immunology
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Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / cerebrospinal fluid
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Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / diagnosis*
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Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / immunology
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Retrospective Studies
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Tumor Necrosis Factor-alpha / cerebrospinal fluid
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Tumor Necrosis Factor-alpha / immunology
Substances
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Biomarkers
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CXCL8 protein, human
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Interleukin-8
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Tumor Necrosis Factor-alpha