Frequency and Predictors of Tenofovir-diphosphate Detection Among Young Kenyan Women in a Real-world Pre-exposure Prophylaxis Implementation Program

Clin Infect Dis. 2020 Dec 3;71(9):e509-e512. doi: 10.1093/cid/ciaa181.

Abstract

In a pre-exposure prophylaxis program for Kenyan women, we detected tenofovir-diphosphate in 61% (125/201) of randomly selected dried blood spots collected at the first follow-up visit. Tenofovir-diphosphate was detected more frequently among women who had partners living with human immunodeficiency virus, who were not pregnant, and who were ≥24 years.

Keywords: HIV/AIDS; adherence; pre-exposure prophylaxis; women.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anti-HIV Agents* / therapeutic use
  • Diphosphates / therapeutic use
  • Emtricitabine / therapeutic use
  • Female
  • HIV Infections* / drug therapy
  • HIV Infections* / epidemiology
  • HIV Infections* / prevention & control
  • Humans
  • Kenya / epidemiology
  • Medication Adherence
  • Pre-Exposure Prophylaxis*
  • Pregnancy
  • Tenofovir / therapeutic use

Substances

  • Anti-HIV Agents
  • Diphosphates
  • Tenofovir
  • Emtricitabine