B7-H3: A promising therapeutic target for autoimmune diseases

Yuting Chen; Shi-Yang Guan; Jixiang Deng; Hui Yang; Wei Xu; Shanshan Xu; Ming Shao; Xing Gao; Shengqian Xu; Zongwen Shuai; Faming Pan

doi:10.1016/j.cellimm.2020.104077

B7-H3: A promising therapeutic target for autoimmune diseases

Cell Immunol. 2020 Jun:352:104077. doi: 10.1016/j.cellimm.2020.104077. Epub 2020 Feb 21.

Authors

Yuting Chen¹, Shi-Yang Guan¹, Jixiang Deng¹, Hui Yang², Wei Xu¹, Shanshan Xu¹, Ming Shao¹, Xing Gao¹, Shengqian Xu³, Zongwen Shuai³, Faming Pan⁴

Affiliations

¹ Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China; The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.
² Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China; Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022,China.
³ Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022,China.
⁴ Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China; The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China. Electronic address: famingpan@ahmu.edu.cn.

PMID: 32113615
DOI: 10.1016/j.cellimm.2020.104077

Abstract

B7-H3 as a newly identified costimulatory molecule that belongs to B7 ligand family, is broadly expressed in both lymphoid and non-lymphoid tissues. The overexpression of B7-H3 has been verified to be correlated with the poor prognosis and poor clinical outcome of several human cancers. In recent years, researchers reveal that B7-H3 is involved in the pathogenesis of various autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), Sjögren's syndrome (SS), ankylosing spondylitis (AS), etc. In this review, we will discuss the biological function of B7-H3 and summarize the progress made over past years regarding its role in the occurrence and development of autoimmune diseases. The insights gained from these findings could serve as the foundation for future therapies of these diseases.

Keywords: Autoimmune diseases; B7-H3; Costimulatory molecule; Therapeutic target.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Autoimmune Diseases / immunology*
Autoimmune Diseases / therapy
B7 Antigens / immunology*
B7 Antigens / metabolism*
Humans

Substances

B7 Antigens
CD276 protein, human