Glycogenic Hepatopathy

Excerpt

Glycogenic hepatopathy (GH) is a rare or possibly under-diagnosed complication seen in children and young adults with poorly controlled type 1 diabetes mellitus and few patients with type 2 diabetes mellitus. It is characterized by a reversible accumulation of excess glycogen in hepatocytes, causing hepatomegaly and transient elevation of liver enzymes, especially transaminases. The diagnosis is confirmed by liver biopsy and staining of glycogen using hematoxylin and eosin (HE) stain.