Seroprevalence, risk factors and comorbidities associated with Helicobacter pylori infection amongst children receiving care at Kilimanjaro Christian Medical Center

Afr Health Sci. 2019 Dec;19(4):3208-3216. doi: 10.4314/ahs.v19i4.44.

Abstract

Background: Helicobacter pylori frequently causes gastritis and peptic ulcers, and affected children are at risk of developing gastric carcinoma later in adulthood.

Methods: This was a Hospital based cross sectional study. A total of 200 children aged 6 months to 14 years were enrolled. Study subjects were tested for H. pylori using a standard serology rapid test measuring immunoglobulin G for H. pylori. For risk factors, Chi-square tests were used to test for association and then, odds ratios and their corresponding 95% confidence intervals and p-values were computed using logistic regression.

Results: The overall seroprevalence of H. pylori was 11.5%. The following factors were associated with H. pylori infection: Age group above 10 years, keeping a dog and household size. The independent predictors of H. pylori were: Fathers' occupation, keeping a dog, indoor tap water, age group, household size and diabetes mellitus type 1..

Conclusion: The seroprevalence of H. pylori antibodies was lower compared to most developing countries. Keeping a dog, household size, indoor tap water, fathers' occupation and diabetes mellitus type 1 were found to be independent predictors of presence of H. pylori antibodies.

Keywords: Helicobacter Pylori.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Age Factors
  • Antibodies, Bacterial / blood*
  • Child
  • Child, Preschool
  • Comorbidity*
  • Cross-Sectional Studies
  • Female
  • Helicobacter Infections / complications*
  • Helicobacter Infections / epidemiology*
  • Helicobacter Infections / immunology*
  • Humans
  • Infant
  • Logistic Models
  • Male
  • Odds Ratio
  • Risk Factors
  • Seroepidemiologic Studies
  • Tanzania / epidemiology

Substances

  • Antibodies, Bacterial