TREM2: Modulator of Lipid Metabolism in Microglia

Neuron. 2020 Mar 4;105(5):759-761. doi: 10.1016/j.neuron.2020.02.008.

Abstract

Lipid-processing mechanisms during demyelination are poorly understood. In this issue of Neuron,Nugent et al. (2020) show by cell-specific lipidomics that Trem2 deficiency leads to cholesterol ester (CE) overload in microglia. This is mediated by misregulation of lipid metabolism genes and is rescued by modulating CE synthesis or efflux.

Keywords: ApoE; Trem2; cholesterol transport; demyelination; lipidomics; microglia; neurodegeneration.

Publication types

  • Comment

MeSH terms

  • Cholesterol
  • Demyelinating Diseases*
  • Humans
  • Lipid Metabolism
  • Membrane Glycoproteins
  • Microglia*
  • Neurons
  • Receptors, Immunologic

Substances

  • Membrane Glycoproteins
  • Receptors, Immunologic
  • TREM2 protein, human
  • Cholesterol