Expression of the hippo signalling pathway effector YAP during canine epidermal tumourigenesis

Res Vet Sci. 2020 Jun:130:93-97. doi: 10.1016/j.rvsc.2020.03.006. Epub 2020 Mar 3.

Abstract

Cutaneous papilloma (CP) and cutaneous squamous cell carcinoma (CSCC) are frequent epidermal tumours in dogs. In this regard, the study of the deregulated activity of signalling molecules during the epidermal tumourigenesis process could be the basis for the development of novel molecular mechanism-based antitumour treatments for CP and CSCC canine patients. Recent evidence suggests that the development and progression of CP and CSCC involve the dysregulated activation of the Hippo signalling pathway effector YAP. Thus, in the present study, we evaluated the immunohistochemical expression pattern of YAP in sections of tissue microarrays constructed from canine samples of normal epidermis, CP, preneoplastic epidermis, and CSCC. In samples of CP, preneoplastic epidermis, and CSCC, YAP expression was significantly increased relative to normal epidermis. This emerging evidence suggests that the dysregulated activity of the Hippo signalling pathway effector YAP represents a frequent event during canine epidermal tumourigenesis, pointing to this protein as a potential therapeutic target for the treatment of CP and CSCC in dogs.

Keywords: Dog skin; Epidermal tumours; Immunohistochemistry; Tissue microarrays; YAP expression.

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics*
  • Adaptor Proteins, Signal Transducing / metabolism
  • Animals
  • Carcinogenesis / genetics*
  • Carcinoma, Squamous Cell / genetics
  • Carcinoma, Squamous Cell / veterinary*
  • Dog Diseases / genetics*
  • Dogs
  • Epidermis / pathology*
  • Gene Expression Profiling / veterinary
  • Papilloma / genetics
  • Papilloma / veterinary*
  • Signal Transduction
  • Skin Neoplasms / genetics
  • Skin Neoplasms / veterinary*
  • Tissue Array Analysis

Substances

  • Adaptor Proteins, Signal Transducing