A Tuft Act to Follow: Leukotrienes Take the Stage in Anti-worm Immunity

Immunity. 2020 Mar 17;52(3):426-428. doi: 10.1016/j.immuni.2020.02.011.

Abstract

Tuft cells are specialized taste-chemosensory cells that detect the presence of intestinal parasites and orchestrate type 2 immunity. In this issue of Immunity, McGinty et al. discover that parasitic worms, but not commensal protists, stimulate tuft cells to release cysteinyl leukotrienes to amplify anti-helminth immunity in the small intestine.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Helminths*
  • Intestinal Mucosa
  • Intestine, Small
  • Leukotrienes
  • Mebendazole*

Substances

  • Leukotrienes
  • Mebendazole