Structural Analogs of Umifenovir. 1. Synthesis and Biological Activity of Ethyl 5-Hydroxy-1-Methyl-2-(Trans-2-Phenylcyclopropyl)-1 H-Indole-3-Carboxylate

J Balzarini; E A Ruchko; E K Zakharova; I Yu Kameneva; M B Nawrozkij

doi:10.1007/s10593-014-1499-y

Structural Analogs of Umifenovir. 1. Synthesis and Biological Activity of Ethyl 5-Hydroxy-1-Methyl-2-(Trans-2-Phenylcyclopropyl)-1 H-Indole-3-Carboxylate

Chem Heterocycl Compd (N Y). 2014;50(4):489-495. doi: 10.1007/s10593-014-1499-y. Epub 2014 Jun 8.

Authors

J Balzarini¹, E A Ruchko², E K Zakharova³, I Yu Kameneva³, M B Nawrozkij³

Affiliations

¹ 1Rega Institute for Medical Research, 10 Minderbroedersstraat, Leuven, B 3000 Belgium.
² Joint-stock Company "Pharm Synthesis", 2, Build. 9 Kabelnaya St., Moscow, 111024 Russia.
³ 3Volgograd State Technical University, 28 Lenin Ave., Volgograd, 400005 Russia.

Abstract

Ethyl 5-hydroxy-1-methyl-2-(trans-2-phenylcyclopropyl)-1H-indole-3-carboxylate is the first prototype of conformationally restricted analogs of umifenovir. It has been prepared using a one-pot method and has undergone an antiviral study.

Keywords: antiviral activity; conformationally restricted analogs; umifenovir.