Imaging of the aging brain and development of MRI signal abnormalities

H Chabriat; E Jouvent

doi:10.1016/j.neurol.2019.12.009

Imaging of the aging brain and development of MRI signal abnormalities

Rev Neurol (Paris). 2020 Nov;176(9):661-669. doi: 10.1016/j.neurol.2019.12.009. Epub 2020 Mar 27.

Authors

H Chabriat¹, E Jouvent²

Affiliations

¹ Inserm U1161 and DHU NeuroVasc, department of neurology, Paris University, Lariboisiere Hospital,Assistance Publique-Hopitaux de Paris, Paris, France. Electronic address: hugues.chabriat@aphp.fr.
² Inserm U1161 and DHU NeuroVasc, department of neurology, Paris University, Lariboisiere Hospital,Assistance Publique-Hopitaux de Paris, Paris, France.

PMID: 32229042
DOI: 10.1016/j.neurol.2019.12.009

Abstract

Major changes occur at the cerebral level with aging. Cerebral atrophy develops progressively. Multiple lesions related to small-vessel diseases are detected in association with cerebral atrophy including white-matter hyperintensities, lacunes, microbleeds, dilated perivascular spaces and cerebral, including cortex, atrophy. The clinical impact and predictive value of these Imaging makers were examined.

Keywords: Aging; Atrophy; Lacunes; Microbleeds; Perivascular spaces; White-matter.

Publication types

Review

MeSH terms

Aging
Atrophy
Brain* / pathology
Cerebral Small Vessel Diseases
Dilatation, Pathologic
Humans
Magnetic Resonance Imaging*