Abstract
We have developed a co-assembled nanosystem based on fenofibrate and ketoprofen by tactfully utilizing their simultaneous benzophenone interaction, which greatly enhances the bioavailability of fenofibrate and plays a role in the dual-targeted treatment of NAFLD by reducing hepatic lipid accumulation and inflammatory responses.
MeSH terms
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Fenofibrate / chemistry
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Fenofibrate / pharmacology*
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Humans
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Inflammation / drug therapy*
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Inflammation / metabolism
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Ketoprofen / chemistry
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Ketoprofen / pharmacology*
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Lipid Metabolism / drug effects
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Molecular Structure
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Non-alcoholic Fatty Liver Disease / drug therapy*
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Non-alcoholic Fatty Liver Disease / metabolism
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Peptides / chemical synthesis
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Peptides / chemistry
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Peptides / pharmacology*
Substances
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Peptides
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Ketoprofen
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Fenofibrate