The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future

Maria C Basil; Jeremy Katzen; Anna E Engler; Minzhe Guo; Michael J Herriges; Jaymin J Kathiriya; Rebecca Windmueller; Alexandra B Ysasi; William J Zacharias; Hal A Chapman; Darrell N Kotton; Jason R Rock; Hans-Willem Snoeck; Gordana Vunjak-Novakovic; Jeffrey A Whitsett; Edward E Morrisey

doi:10.1016/j.stem.2020.03.009

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future

Cell Stem Cell. 2020 Apr 2;26(4):482-502. doi: 10.1016/j.stem.2020.03.009.

Authors

Maria C Basil¹, Jeremy Katzen¹, Anna E Engler², Minzhe Guo³, Michael J Herriges², Jaymin J Kathiriya⁴, Rebecca Windmueller¹, Alexandra B Ysasi², William J Zacharias³, Hal A Chapman⁴, Darrell N Kotton², Jason R Rock², Hans-Willem Snoeck⁵, Gordana Vunjak-Novakovic⁶, Jeffrey A Whitsett², Edward E Morrisey⁷

Affiliations

¹ Department of Medicine, Penn-CHOP Lung Biology Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
² Center for Regenerative Medicine of Boston University and Boston Medical Center, The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA 02215, USA.
³ Division of Pulmonary Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.
⁴ Division of Pulmonary Medicine, Department of Medicine, University of California-San Francisco, San Francisco, CA 94143, USA.
⁵ Center for Human Development, Department of Medicine, Columbia University, New York, NY 10027, USA.
⁶ Departments of Biomedical Engineering and Medicine, Columbia University, New York, NY 10027, USA.
⁷ Department of Medicine, Penn-CHOP Lung Biology Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: emorrise@pennmedicine.upenn.edu.

Abstract

The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex multi-cellular organ that intimately links with the cardiovascular system to accomplish gas exchange. In this review and as members of the NIH/NHLBI-supported Progenitor Cell Translational Consortium, we discuss key aspects of lung repair and regeneration. We focus on the cellular compositions within functional niches, cell-cell signaling in homeostatic health, the responses to injury, and new methods to study lung repair and regeneration. We also provide future directions for an improved understanding of the cell biology of the respiratory system, as well as new therapeutic avenues.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Cell Communication
Lung*
Pulmonary Alveoli
Stem Cells*
Trachea

Abstract

Publication types

MeSH terms

Grants and funding