An Update on the Pathophysiology and Treatment of Cardiorenal Syndrome

Rupesh Raina; Nikhil Nair; Ronith Chakraborty; Lena Nemer; Rahul Dasgupta; Kenneth Varian

doi:10.14740/cr955

An Update on the Pathophysiology and Treatment of Cardiorenal Syndrome

Cardiol Res. 2020 Apr;11(2):76-88. doi: 10.14740/cr955. Epub 2020 Mar 10.

Authors

Rupesh Raina^{1

2

3

4}, Nikhil Nair^{5

4}, Ronith Chakraborty¹, Lena Nemer¹, Rahul Dasgupta⁵, Kenneth Varian⁶

Affiliations

¹ Department of Nephrology, Akron Nephrology Associates at Cleveland Clinic Akron General Medical Center, Akron, OH, USA.
² Department of Pediatric Nephrology, Akron Children's Hospital, Akron, OH, USA.
³ Northeast Ohio Medical School, Rootstown, OH, USA.
⁴ These authors contributed equally to this article.
⁵ Department of Chemistry, Case Western Reserve University, Cleveland, OH, USA.
⁶ Department of Cardiology, Summa Health, Akron, OH, USA.

PMID: 32256914
PMCID: PMC7092771
DOI: 10.14740/cr955

Abstract

Cardiorenal syndrome (CRS) encompasses various disorders of the heart and kidneys; dysfunction of one organ leads to acute or chronic dysfunction of the other. It incorporates the intersection of heart-kidney interactions across several mediums, hemodynamically, through the alterations in neurohormonal markers, and increased venous and renal pressure, all of which are hallmarks of its clinical phenotypes. This article explores the epidemiology, pathology, classification and treatment of each type of CRS.

Keywords: Cardiorenal syndrome; Chronic kidney disease; Heart failure.

Publication types

Review