Abstract
Higher-order supramolecular complexes-dubbed signalosomes carry out key signaling and effector functions in innate immunity and inflammation. In this review, we present several recently discovered signalosomes that are formed either by stable protein-protein interactions or by dynamic liquid-liquid phase separation. Structural features of these signalosomes are highlighted to elucidate their functions and biological insights.
Copyright © 2020 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Biology
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Cell Physiological Phenomena* / genetics
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Humans
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Immunity, Innate / genetics
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Immunity, Innate / physiology*
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Inflammation / genetics
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Inflammation / immunology
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Inflammation / metabolism*
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Inflammation / pathology
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Macromolecular Substances / metabolism*
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Organelles / metabolism*
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Organelles / physiology
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Protein Binding
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Protein Multimerization / physiology*
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Signal Transduction / genetics
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Signal Transduction / physiology
Substances
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Macromolecular Substances