Hypereosinophilia-related liver pseudotumor with elevated interleukin-5 levels preceding T-cell lymphoma

Atsunori Tsuchiya; Tomoyuki Tanaka; Yasuhiko Shibasaki; Shuji Terai

doi:10.1002/jgh3.12253

Hypereosinophilia-related liver pseudotumor with elevated interleukin-5 levels preceding T-cell lymphoma

JGH Open. 2019 Sep 6;4(2):312-314. doi: 10.1002/jgh3.12253. eCollection 2020 Apr.

Authors

Atsunori Tsuchiya¹, Tomoyuki Tanaka², Yasuhiko Shibasaki², Shuji Terai¹

Affiliations

¹ Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences Niigata University Niigata Japan.
² Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine Niigata University Niigata Japan.

Abstract

A 61-year-old woman with hypereosinophilia and elevated interleukin (IL)-5 level was admitted to our hospital after detection of multiple liver tumors. Liver biopsy demonstrated that the tumor consisted of scar tissue with remnants of eosinophilic infiltration, suggesting that it had formed by massive eosinophilic infiltration. The hypereosinophilia was treated mainly by prednisolone, and thereafter, the liver tumors disappeared. However, 10 months postadmission, CD4+ T-cell lymphoma, which can produce IL-5, was detected in the nasopharynx and oropharynx. Therefore, we believe that this is a rare case of hypereosinophilia-related liver pseudotumor induced by presumed by IL-5 elevation.

Keywords: hypereosinophilia; interleukin‐5; malignant lymphoma; multiple liver tumors; ultrasonography.

Publication types

Case Reports