Socio-ecological correlates of physical activity in breast and colon cancer survivors 4 years after participation in a randomized controlled exercise trial (PACT study)

PLoS One. 2020 Apr 16;15(4):e0231663. doi: 10.1371/journal.pone.0231663. eCollection 2020.

Abstract

Background: Having a physically active lifestyle after cancer diagnosis is beneficial for health, and this needs to be continued into survivorship to optimize long-term benefits. We found that patients, who participated in an 18-week exercise intervention, reported significant higher physical activity (PA) levels 4 years after participation in a randomized controlled trial of supervised exercise delivered during chemotherapy (PACT study). This study aimed to identify social-ecological correlates of PA levels in breast and colon cancer survivors 4 years after participation in the PACT study.

Methods: Self-reported PA levels and potential correlates (e.g. physical fitness, fatigue, exercise history, and built environment) were assessed in 127 breast and colon cancer survivors shortly after diagnosis (baseline), post-intervention and 4 years later. Multivariable linear regression analyses were performed to identify social-ecological correlates of PA 4 years post-baseline.

Results: The final model revealed that lower baseline physical fatigue (β = -0.25, 95% CI -0.26; -0.24) and higher baseline total PA (0.06, 95% CI, 0.03; 0.10) were correlated with higher total PA levels 4 years post-baseline. Higher baseline leisure and sport PA (0.02, 95% CI 0.01; 0.03), more recreational facilities within a buffer of 1 km (4.05, 95% CI = 1.28; 6.83), lower physical fatigue at 4-year follow-up (-8.07, 95% CI -14.00; -2.13), and having a positive change in physical fatigue during the intervention period (0.04, 95% CI 0.001; 0.07) were correlates of sport and leisure PA levels 4 years post-baseline.

Conclusions: This study suggests that baseline and 4-year post-baseline physical fatigue, and past exercise behaviour, were significant correlates of PA 4 years after participation in an exercise trial. Additionally, this study suggests that the built environment should be taken into account when promoting PA. Understanding of socio-ecological correlates of PA can provide insights into how future exercise interventions should be designed to promote long-term exercise behaviour.

Trial registration: Current Controlled Trials ISRCTN43801571, Dutch Trial Register NTR2138. Trial registered on 9 December 2009, http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2138.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Breast Neoplasms / epidemiology
  • Breast Neoplasms / therapy*
  • Cancer Survivors
  • Colonic Neoplasms / epidemiology
  • Colonic Neoplasms / therapy*
  • Exercise Therapy* / methods
  • Fatigue / etiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Physical Fitness
  • Socioeconomic Factors
  • Survival Analysis

Associated data

  • ISRCTN/ISRCTN43801571
  • NTR/NTR2138

Grants and funding

This work was supported by The Netherlands Organisation for Health Research and Development (ZonMw, project number: 171002202, https://www.zonmw.nl/nl/onderzoek-resultaten/doelmatigheidsonderzoek/programmas/project-detail/doelmatigheidsonderzoek/physical-activity-during-cancer-treatment-pact-studie-een-gerandomiseerde-studie-naar-de-effecten/, PHMP), the Dutch Cancer Society (KWF Kankerbestrijding. Project number: UU 2009-4473, PHMP), the Dutch Pink Ribbon Foundation (2011.WO02.C100, https://www.pinkribbon.nl/doelbestedingen/wetenschappelijk-onderzoek/2011/pact-studie.html, AMM) and VIOZ (Stichting Vrienden Integrale Oncologische Zorg (2015, MJV). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.