Delirium in intensive care: A stepped-wedge cluster randomised controlled trial for a nurse-led intervention to reduce the incidence and duration of delirium among adults admitted to the intensive care unit (protocol)

Joan Lynch; Kaye Rolls; Yu Chin Hou; Sonja Hedges; Masar Al Sayfe; Sharon-Ann Shunker; Kathleen Brennan; David Sanchez; Tony Bogdanovski; Leanne Hunt; Evan Alexandrou; Steven A Frost

doi:10.1016/j.aucc.2019.12.003

Delirium in intensive care: A stepped-wedge cluster randomised controlled trial for a nurse-led intervention to reduce the incidence and duration of delirium among adults admitted to the intensive care unit (protocol)

Aust Crit Care. 2020 Sep;33(5):475-479. doi: 10.1016/j.aucc.2019.12.003. Epub 2020 Apr 19.

Authors

Affiliations

¹ Critical Care Research in Collaboration and Evidence Translation (CCRICET), Australia; School of Nursing and Midwifery, Western Sydney University, Australia; Intensive Care Unit Liverpool Hospital, Australia.
² Critical Care Research in Collaboration and Evidence Translation (CCRICET), Australia; School of Nursing and Midwifery, Western Sydney University, Australia; Intensive Care Fairfield Hospital, Australia; School of Nursing, University of Wollongong, Australia. Electronic address: Kaye.rolls@westernsydney.edu.au.
³ Critical Care Research in Collaboration and Evidence Translation (CCRICET), Australia; Intensive Care Unit Liverpool Hospital, Australia; Centre for Applied Nursing Research, SWSLHD, Australia.
⁴ Critical Care Research in Collaboration and Evidence Translation (CCRICET), Australia; Intensive Care Bankstown Hospital, Australia; Centre for Applied Nursing Research, SWSLHD, Australia.
⁵ Intensive Care Fairfield Hospital, Australia.
⁶ Intensive Care Unit Liverpool Hospital, Australia.
⁷ Critical Care Research in Collaboration and Evidence Translation (CCRICET), Australia; Intensive Care Unit Campbelltown Hospital, South Western Sydney Local Health District, Australia.
⁸ Critical Care Research in Collaboration and Evidence Translation (CCRICET), Australia; School of Nursing and Midwifery, Western Sydney University, Australia; Intensive Care Unit Liverpool Hospital, Australia; Centre for Applied Nursing Research, SWSLHD, Australia.

PMID: 32317213
DOI: 10.1016/j.aucc.2019.12.003

Abstract

Background: Delirium is an acute disorder of attention and cognition with the highest rates among adults receiving intensive care. An acute episode of delirium is associated with morbidity and mortality, as well as a significant psychological sequela. Importantly, an increasing body of evidence supports the benefit of nonpharmacological, nurse-led interventions to reduce the incidence and duration of delirium among adults cared for in the intensive care unit (ICU).

Objectives: This study will evaluate the impact of a nursing-led delirium prevention protocol that is aimed at reducing the incidence and duration of delirium among adults admitted to the ICU. The delirium prevention nursing protocol specifically targets risk factors for delirium.

Study plan: A stepped-wedge cluster randomised controlled trial approach will be used to assess the effectiveness of the nurse-led intervention, in four adult ICUs across the South Western Sydney Local Health District (SWS-LHD), over a 12-month period. The primary outcomes of interest are (i) the incidence of delirium before and after the implementation of the nurse-led intervention and (ii) the number of delirium-free days during an ICU stay, before and after the implementation of the nurse-led intervention.

Trial registration: Australian New Zealand Clinical Trials Registry (ANZCTR): (ACTRN12618000411246p).

Keywords: Critical illness; Delirium; Intensive care; Intensive care nursing; Step wedge randomised control trial.

Publication types

Clinical Trial Protocol
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Australia / epidemiology
Critical Care
Delirium* / epidemiology
Delirium* / prevention & control
Humans
Incidence
Intensive Care Units
Nurse's Role*
Randomized Controlled Trials as Topic