COPD sputum eosinophils: relationship to blood eosinophils and the effect of inhaled PDE4 inhibition

Eur Respir J. 2020 Aug 6;56(2):2000237. doi: 10.1183/13993003.00237-2020. Print 2020 Aug.

Abstract

PDE4 inhibition reduces sputum eosinophils in those COPD patients with higher eosinophil counts. This evidence supports an effect of PDE4 inhibitors on eosinophilic inflammation. https://bit.ly/3airXw7

Trial registration: ClinicalTrials.gov NCT03004417.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Eosinophils*
  • Humans
  • Leukocyte Count
  • Pulmonary Disease, Chronic Obstructive* / drug therapy
  • Sputum

Associated data

  • ClinicalTrials.gov/NCT03004417
  • EudraCT/2015-005550-35