Chinese Medicine Treatment on Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

Chin J Integr Med. 2020 May;26(5):324-329. doi: 10.1007/s11655-020-3252-y. Epub 2020 Apr 29.

Abstract

Graft-versus-host disease (GVHD) is the most common complication after allogeneic hematopoietic stem cell transplantation, and also an important factor affecting the survival and quality of life in patients after transplantation. Currently, immunosuppressive therapy is commonly used for GVHD, but the curative effect is not ideal. How to effectively prevent and treat GVHD is one of the difficulties to be solved urgently in the field of transplantation. In this paper, we summarize the latest progress in pathogenesis, prevention and treatment of GVHD with Chinese medicine (CM). We hope it will provide ideas and methods for exploring the mechanism and establishing a new comprehensive therapy for GVHD with CM.

Keywords: Chinese medicine; graft-versus-host disease; hematopoietic stem cell transplantation.

MeSH terms

  • Allografts
  • Graft vs Host Disease / drug therapy*
  • Graft vs Host Disease / etiology*
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Medicine, Chinese Traditional*
  • Quality of Life