Association of Adjuvant Chemotherapy With Overall Survival in Patients With Early-Stage Breast Cancer and 21-Gene Recurrence Scores of 26 or Higher

Sung Jun Ma; Oluwadamilola T Oladeru; Anurag K Singh

doi:10.1001/jamanetworkopen.2020.3876

Association of Adjuvant Chemotherapy With Overall Survival in Patients With Early-Stage Breast Cancer and 21-Gene Recurrence Scores of 26 or Higher

JAMA Netw Open. 2020 May 1;3(5):e203876. doi: 10.1001/jamanetworkopen.2020.3876.

Authors

Sung Jun Ma¹, Oluwadamilola T Oladeru², Anurag K Singh¹

Affiliations

¹ Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
² Department of Radiation Oncology, Massachusetts General Hospital, Boston.

Abstract

This cohort study investigates the association of overall survival with receiving chemotherapy among patients with early-stage breast cancer and recurrence scores of 26 to 30 vs those with recurrence scores of 31 or greater.

MeSH terms

Aged
Breast Neoplasms / drug therapy
Breast Neoplasms / genetics
Breast Neoplasms / mortality*
Chemotherapy, Adjuvant
Disease-Free Survival
Female
Gene Expression Profiling
Humans
Neoplasm Recurrence, Local / drug therapy
Neoplasm Recurrence, Local / genetics
Neoplasm Recurrence, Local / mortality*
Receptor, ErbB-2 / genetics
United States

Substances

Receptor, ErbB-2