Inflammation's Epigenetic Footprint in Hematopoietic Stem Cells

Sarah S Geiger; Marieke A G Essers

doi:10.1016/j.stem.2020.04.015

Inflammation's Epigenetic Footprint in Hematopoietic Stem Cells

Cell Stem Cell. 2020 May 7;26(5):611-612. doi: 10.1016/j.stem.2020.04.015.

Authors

Sarah S Geiger¹, Marieke A G Essers²

Affiliations

¹ Division Inflammatory Stress in Stem Cells, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGMBH), 69120 Heidelberg, Germany.
² Division Inflammatory Stress in Stem Cells, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGMBH), 69120 Heidelberg, Germany; DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany. Electronic address: m.essers@dkfz.de.

PMID: 32386549
DOI: 10.1016/j.stem.2020.04.015

Abstract

Immune memory was thought to be unique to cells of the adaptive immune system. In this issue of Cell Stem Cell, de Laval et al. (2020) describe persistent epigenetic modifications in hematopoietic stem cells following an inflammatory insult with LPS as a mechanism by which immune memory may be established.

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MeSH terms

CCAAT-Enhancer-Binding Protein-beta*
Epigenesis, Genetic
Hematopoietic Stem Cells*
Humans
Immune System
Inflammation / genetics

Substances

CCAAT-Enhancer-Binding Protein-beta