SARS-CoV-2: Combating Coronavirus Emergence

Rachel L Graham; Ralph S Baric

doi:10.1016/j.immuni.2020.04.016

SARS-CoV-2: Combating Coronavirus Emergence

Immunity. 2020 May 19;52(5):734-736. doi: 10.1016/j.immuni.2020.04.016. Epub 2020 May 8.

Authors

Rachel L Graham¹, Ralph S Baric²

Affiliations

¹ Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
² Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: rbaric@email.unc.edu.

Abstract

The emergence and rapid global spread of SARS-CoV-2 mark the third such identification of a novel coronavirus capable of causing severe, potentially fatal disease in humans in the 21^st century. As noted by Andersen et al. (Nature Medicine), the sequencing of proximal zoonotic ancestors to SARS-CoV-2 has aided in the identification of alleles that may contribute to the virus' virulence in humans.

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MeSH terms

Betacoronavirus
COVID-19
Coronavirus Infections*
Coronavirus*
Humans
Pandemics
Pneumonia, Viral
SARS-CoV-2
Severe acute respiratory syndrome-related coronavirus*