Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes

Affiliations

• ¹ Key Laboratory of Metabolism and Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, 200030, China.
• ² Institute of Stem Cell Research and Regenerative Medicine, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200030, China.
• ³ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
• ⁴ Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, 200438, China.
• ⁵ Henan Sesame Research Center, Henan Academy of Agricultural Sciences, Zhengzhou, 450002, China.
• ⁶ College of Traditional Mongolian Medicine, Inner Mongolia Medical University, Mongolia, 010110, China.
• ⁷ State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China.
• ⁸ Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China.
• ⁹ Department of Physiology, Cardiovascular Research Institute, University of California San Francisco, San Francisco, USA.
• ¹⁰ Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
• ¹¹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. cluo@simm.ac.cn.
• ¹² State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China. byu@sioc.ac.cn.
• ¹³ Key Laboratory of Metabolism and Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, 200030, China. qqtang@shmu.edu.cn.
• ¹⁴ Institute of Stem Cell Research and Regenerative Medicine, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200030, China. qqtang@shmu.edu.cn.
• ¹⁵ Key Laboratory of Metabolism and Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, 200030, China. yongjundang@fudan.edu.cn.