Comparison of Lutetium-177 tin colloid and Rhenium-188 tin colloid radiosynovectomy in chronic knee arthritis

Nucl Med Commun. 2020 Aug;41(8):721-726. doi: 10.1097/MNM.0000000000001210.

Abstract

Objective: To assess the role of Lutetium-177(Lu-177) tin colloid for radiosynovectomy and compare it with Rhenium-188 (Re-188) tin colloid radiosynovectomy for alleviation of pain in patients with chronic inflammatory arthritis of knee.

Methods: Patients of chronic inflammatory arthritis of the knee underwent pretherapeutic evaluation in a form of knee ultrasonogram, bone scan and clinical evaluation. Fifty-seven recruited patients were allocated at random to receive either intraarticular injections of Lu-177 tin colloid or Re-188 tin colloid. Eventually, 27 patients received Re-188 tin colloid and 30 patients received Lu-177 tin colloid. The joint was then immobilized for 2 days. Response evaluation was done using knee ultrasound, bone scan and clinical findings.

Result: Of 30, 20 patients responded to radiosynovectomy in the Lu-177 tin colloid group compared to 21/27 patients in the Re-188 tin colloid group.

Conclusion: Lu-177 tin colloid is an effective alternative to Re-188 tin colloid for radiosynovectomy in patients with chronic inflammatory knee arthritis.

Publication types

  • Comparative Study

MeSH terms

  • Chronic Disease
  • Female
  • Humans
  • Lutetium / therapeutic use*
  • Male
  • Middle Aged
  • Osteoarthritis, Knee / surgery*
  • Radioisotopes / therapeutic use*
  • Radiosurgery / methods*
  • Rhenium / therapeutic use*
  • Severity of Illness Index
  • Synovectomy / methods*
  • Tin / therapeutic use*

Substances

  • (188)Rhenium tin-colloid
  • Radioisotopes
  • Lutetium
  • Rhenium
  • Tin
  • Lutetium-177