A rare association of Mycobacterium tuberculosis infection of kidney and urinary tract with immunoglobulin A nephropathy

Indian J Med Microbiol. 2019 Oct-Dec;37(4):587-589. doi: 10.4103/ijmm.IJMM_19_482.

Abstract

Mycobacterium tuberculosis(MTB)-related secondary immunoglobulin A (IgA) nephropathy is reported in a 72-year-old male patient. The patient was diagnosed to have MTB infection of the kidney and genitourinary tract which was diagnosed by the demonstration of the organism by GeneXpert Ultra and culture. Concurrent kidney biopsy showed IgA nephropathy. The patient responded to urethral double-J stenting and four-drug antituberculous therapy with improvement of kidney function and resolution of MTB. IgA nephropathy can present as primary glomerulonephritis or secondary to MTB infection.

Keywords: Genitourinary tuberculosis; immunoglobulin A nephropathy; obstructive uropathy.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antitubercular Agents / therapeutic use
  • Glomerulonephritis, IGA / drug therapy
  • Glomerulonephritis, IGA / microbiology*
  • Humans
  • Immunoglobulin A / immunology*
  • Kidney / microbiology*
  • Male
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / immunology*
  • Tuberculosis / drug therapy
  • Tuberculosis / immunology*
  • Urinary Tract / immunology
  • Urinary Tract / microbiology*
  • Urinary Tract Infections / drug therapy
  • Urinary Tract Infections / immunology
  • Urinary Tract Infections / microbiology*

Substances

  • Antitubercular Agents
  • Immunoglobulin A