RIFM fragrance ingredient safety assessment, citral, CAS Registry Number 5392-40-5

A M Api; D Belsito; S Biserta; D Botelho; M Bruze; G A Burton Jr; J Buschmann; M A Cancellieri; M L Dagli; M Date; W Dekant; C Deodhar; A D Fryer; S Gadhia; L Jones; K Joshi; A Lapczynski; M Lavelle; D C Liebler; M Na; D O'Brien; A Patel; T M Penning; G Ritacco; F Rodriguez-Ropero; J Romine; N Sadekar; D Salvito; T W Schultz; F Siddiqi; I G Sipes; G Sullivan; Y Thakkar; Y Tokura; S Tsang

doi:10.1016/j.fct.2020.111339

RIFM fragrance ingredient safety assessment, citral, CAS Registry Number 5392-40-5

Food Chem Toxicol. 2020 Jul 15:141 Suppl 1:111339. doi: 10.1016/j.fct.2020.111339. Epub 2020 May 18.

Authors

A M Api¹, D Belsito², S Biserta¹, D Botelho¹, M Bruze³, G A Burton Jr⁴, J Buschmann⁵, M A Cancellieri¹, M L Dagli⁶, M Date¹, W Dekant⁷, C Deodhar¹, A D Fryer⁸, S Gadhia¹, L Jones¹, K Joshi¹, A Lapczynski¹, M Lavelle¹, D C Liebler⁹, M Na¹, D O'Brien¹, A Patel¹, T M Penning¹⁰, G Ritacco¹, F Rodriguez-Ropero¹, J Romine¹, N Sadekar¹, D Salvito¹, T W Schultz¹¹, F Siddiqi¹, I G Sipes¹², G Sullivan¹³, Y Thakkar¹, Y Tokura¹⁴, S Tsang¹

Affiliations

¹ Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
² Member Expert Panel, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY, 10032, USA.
³ Member Expert Panel, Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo, SE-20502, Sweden.
⁴ Member Expert Panel, School of Natural Resources & Environment, University of Michigan, Dana Building G110, 440 Church St., Ann Arbor, MI, 58109, USA.
⁵ Member Expert Panel, Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Strasse 1, 30625, Hannover, Germany.
⁶ Member Expert Panel, University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo, CEP 05508-900, Brazil.
⁷ Member Expert Panel, University of Wuerzburg, Department of Toxicology, Versbacher Str. 9, 97078, Würzburg, Germany.
⁸ Member Expert Panel, Oregon Health Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA.
⁹ Member Expert Panel, Vanderbilt University School of Medicine, Department of Biochemistry, Center in Molecular Toxicology, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN, 37232-0146, USA.
¹⁰ Member of Expert Panel, University of Pennsylvania, Perelman School of Medicine, Center of Excellence in Environmental Toxicology, 1316 Biomedical Research Building (BRB) II/III, 421 Curie Boulevard, Philadelphia, PA, 9104-3083, USA.
¹¹ Member Expert Panel, The University of Tennessee, College of Veterinary Medicine, Department of Comparative Medicine, 2407 River Dr., Knoxville, TN, 37996- 4500, USA.
¹² Member Expert Panel, Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ, 85724-5050, USA.
¹³ Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA. Electronic address: gsullivan@rifm.org.
¹⁴ Member Expert Panel, The Journal of Dermatological Science (JDS), Editor-in-Chief, Professor and Chairman, Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

PMID: 32439587
DOI: 10.1016/j.fct.2020.111339

No abstract available

Keywords: Environmental safety; Genotoxicity; Local respiratory toxicity; Phototoxicity/photoallergenicity; Repeated dose, developmental, and reproductive toxicity; Skin sensitization.

Publication types

Review

MeSH terms

Acyclic Monoterpenes / chemistry
Acyclic Monoterpenes / toxicity*
Animals
Databases, Chemical
Humans
No-Observed-Adverse-Effect Level
Odorants*
Perfume
Registries
Risk Assessment
Toxicity Tests*

Substances

Acyclic Monoterpenes
Perfume
citral