Neuroimaging studies within Cognitive Genetics Collaborative Research Organization aiming to replicate and extend works of ENIGMA

Daisuke Koshiyama; Kenichiro Miura; Kiyotaka Nemoto; Naohiro Okada; Junya Matsumoto; Masaki Fukunaga; Ryota Hashimoto

doi:10.1002/hbm.25040

Neuroimaging studies within Cognitive Genetics Collaborative Research Organization aiming to replicate and extend works of ENIGMA

Hum Brain Mapp. 2022 Jan;43(1):182-193. doi: 10.1002/hbm.25040. Epub 2020 Jun 5.

Authors

Daisuke Koshiyama¹, Kenichiro Miura², Kiyotaka Nemoto³, Naohiro Okada^{1

4}, Junya Matsumoto², Masaki Fukunaga⁵, Ryota Hashimoto²

Affiliations

¹ Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
² Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
³ Department of Psychiatry, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
⁴ International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, Tokyo, Japan.
⁵ Division of Cerebral Integration, National Institute for Physiological Sciences, Okazaki, Aichi, Japan.

Abstract

Reproducibility is one of the most important issues for generalizing the results of clinical research; however, low reproducibility in neuroimaging studies is well known. To overcome this problem, the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium, an international neuroimaging consortium, established standard protocols for imaging analysis and employs either meta- and mega-analyses of psychiatric disorders with large sample sizes. The Cognitive Genetics Collaborative Research Organization (COCORO) in Japan promotes neurobiological studies in psychiatry and has successfully replicated and extended works of ENIGMA especially for neuroimaging studies. For example, (a) the ENIGMA consortium showed subcortical regional volume alterations in patients with schizophrenia (n = 2,028) compared to controls (n = 2,540) across 15 cohorts using meta-analysis. COCORO replicated the volumetric changes in patients with schizophrenia (n = 884) compared to controls (n = 1,680) using the ENIGMA imaging analysis protocol and mega-analysis. Furthermore, a schizophrenia-specific leftward asymmetry for the pallidum volume was demonstrated; and (b) the ENIGMA consortium identified white matter microstructural alterations in patients with schizophrenia (n = 1,963) compared to controls (n = 2,359) across 29 cohorts. Using the ENIGMA protocol, a study from COCORO showed similar results in patients with schizophrenia (n = 696) compared to controls (n = 1,506) from 12 sites using mega-analysis. Moreover, the COCORO study found that schizophrenia, bipolar disorder (n = 211) and autism spectrum disorder (n = 126), but not major depressive disorder (n = 398), share similar white matter microstructural alterations, compared to controls. Further replication and harmonization of the ENIGMA consortium and COCORO will contribute to the generalization of their research findings.

Keywords: magnetic resonance imaging (MRI); mega-analysis; meta-analysis; neuroimaging; psychiatric disorders; reproducibility; schizophrenia.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Genetics
Gray Matter / diagnostic imaging
Gray Matter / pathology*
Humans
Magnetic Resonance Imaging*
Mental Disorders / diagnostic imaging
Mental Disorders / pathology*
Meta-Analysis as Topic
Multicenter Studies as Topic
Neuroimaging*
White Matter / diagnostic imaging
White Matter / pathology*