Intra-abdominal hypertension as a trigger of "gut failure" in SARS-CoV-2 infection: Effect of open abdomen (OA) and negative pressure therapy (NPT) on respiratory and gastrointestinal (GI) function

Med Hypotheses. 2020 Nov:144:109954. doi: 10.1016/j.mehy.2020.109954. Epub 2020 Jun 5.

Abstract

COVID-19 gastrointestinal manifestations could be attributed to SARS-CoV-2-induced small vessel thrombosis. OA with NPT treatment may have a role in optimization of bowel microcirculation and in the reduction of the endothelial and the systemic cytokine-related damage, improving also respiratory function.

MeSH terms

  • COVID-19 / complications*
  • Cytokines / physiology
  • Gastrointestinal Diseases / etiology*
  • Gastrointestinal Diseases / physiopathology
  • Gastrointestinal Diseases / therapy*
  • Gastrointestinal Tract / blood supply
  • Gastrointestinal Tract / physiopathology
  • Humans
  • Intra-Abdominal Hypertension / etiology*
  • Intra-Abdominal Hypertension / physiopathology
  • Intra-Abdominal Hypertension / therapy*
  • Microcirculation
  • Models, Biological
  • Negative-Pressure Wound Therapy / methods*
  • Open Abdomen Techniques / methods*
  • Pandemics

Substances

  • Cytokines