Psoriasis-associated impairment of CCL27/CCR10-derived regulation leads to IL-17A/IL-22-producing skin T-cell overactivation

Chao Li; Ming Xu; James Coyne; Wei-Bei Wang; Micha L Davila; Yong Wang; Na Xiong

doi:10.1016/j.jaci.2020.05.044

Psoriasis-associated impairment of CCL27/CCR10-derived regulation leads to IL-17A/IL-22-producing skin T-cell overactivation

J Allergy Clin Immunol. 2021 Feb;147(2):759-763.e9. doi: 10.1016/j.jaci.2020.05.044. Epub 2020 Jun 10.

Authors

Chao Li¹, Ming Xu², James Coyne³, Wei-Bei Wang⁴, Micha L Davila², Yong Wang⁵, Na Xiong⁶

Affiliations

¹ Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center San Antonio, San Antonio, Tex; Department of Veterinary and Biomedical Sciences, Centre for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, Pa; Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China.
² Department of Veterinary and Biomedical Sciences, Centre for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, Pa.
³ Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pa.
⁴ Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center San Antonio, San Antonio, Tex; Department of Veterinary and Biomedical Sciences, Centre for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, Pa.
⁵ Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pa. Electronic address: yxw30@psu.edu.
⁶ Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center San Antonio, San Antonio, Tex; Department of Veterinary and Biomedical Sciences, Centre for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, Pa. Electronic address: xiongn@uthscsa.edu.

Abstract

Psoriasis-associated suppression of the skin-specific chemokine/receptor CCL27/CCR10 axis leads to enhanced pathogenic IL-17A/IL-22-producing skin T cell activation and inflammation.

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Animals
Chemokine CCL27 / immunology*
Interleukin-17 / immunology
Interleukin-22
Interleukins / immunology
Lymphocyte Activation / immunology*
Mice
Psoriasis / immunology*
Receptors, CCR10 / immunology*
Skin / immunology
T-Lymphocytes / immunology*

Substances

Chemokine CCL27
Interleukin-17
Interleukins
Receptors, CCR10

Abstract

Publication types

MeSH terms

Substances

Grants and funding