Smoking cessation improves clinical outcome in severe mental disorders and is modulated by genetic variability at CHRNA5 gene

A G Segura; M Mitjans; M Fatjó-Vilas; M P Garcia-Portilla; L Garcia-Alvarez; F Sarramea; T Bobes-Bascaran; L de la Fuente-Tomás; A Velasco Iglesias; C Martínez-Cao; L González-Blanco; F Dal Santo; E Elizagarate; P A Saiz; L Fañanás; J Bobes; B Arias

doi:10.1016/j.schres.2020.05.024

Smoking cessation improves clinical outcome in severe mental disorders and is modulated by genetic variability at CHRNA5 gene

Schizophr Res. 2020 Aug:222:516-519. doi: 10.1016/j.schres.2020.05.024. Epub 2020 Jun 14.

Authors

A G Segura¹, M Mitjans², M Fatjó-Vilas³, M P Garcia-Portilla⁴, L Garcia-Alvarez⁵, F Sarramea⁶, T Bobes-Bascaran⁷, L de la Fuente-Tomás⁵, A Velasco Iglesias⁵, C Martínez-Cao⁸, L González-Blanco⁴, F Dal Santo⁹, E Elizagarate¹⁰, P A Saiz⁴, L Fañanás², J Bobes⁴, B Arias¹¹

Affiliations

¹ Evolutive Biology, Ecology and Environmental Sciences Department, Faculty of Biology, University of Barcelona, Institute of Biomedicine of the University of Barcelona (IBUB), Avinguda Diagonal, 643, 08028 Barcelona, Spain.
² Evolutive Biology, Ecology and Environmental Sciences Department, Faculty of Biology, University of Barcelona, Institute of Biomedicine of the University of Barcelona (IBUB), Avinguda Diagonal, 643, 08028 Barcelona, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain.
³ Evolutive Biology, Ecology and Environmental Sciences Department, Faculty of Biology, University of Barcelona, Institute of Biomedicine of the University of Barcelona (IBUB), Avinguda Diagonal, 643, 08028 Barcelona, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain; FIDMAG Germanes Hospitalaries Research Foundation, Av. Jordà, 8, 08035 Barcelona, Spain.
⁴ Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain; Department of Psychiatry, University of Oviedo, c/ Julián Claveria s/n, 33006 Oviedo, Asturias, Spain.; Mental Health Services of the Principality of Asturias (SESPA), Plaza del Carbayón, 1, 33001 Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Av. Roma, s/n, 33011 Oviedo, Spain; Instituto de Neurociencias del Principado de Asturias (INEUROPA), Plaza Feijóo s/n, 33003 Oviedo, Spain.
⁵ Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain; Department of Psychiatry, University of Oviedo, c/ Julián Claveria s/n, 33006 Oviedo, Asturias, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Av. Roma, s/n, 33011 Oviedo, Spain; Instituto de Neurociencias del Principado de Asturias (INEUROPA), Plaza Feijóo s/n, 33003 Oviedo, Spain.
⁶ Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain; Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Av. Menendez Pidal, s/n, 14004 Córdoba, Spain.
⁷ Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain; Mental Health Services of the Principality of Asturias (SESPA), Plaza del Carbayón, 1, 33001 Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Av. Roma, s/n, 33011 Oviedo, Spain; Instituto de Neurociencias del Principado de Asturias (INEUROPA), Plaza Feijóo s/n, 33003 Oviedo, Spain.
⁸ Department of Psychiatry, University of Oviedo, c/ Julián Claveria s/n, 33006 Oviedo, Asturias, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Av. Roma, s/n, 33011 Oviedo, Spain; Instituto de Neurociencias del Principado de Asturias (INEUROPA), Plaza Feijóo s/n, 33003 Oviedo, Spain.
⁹ Department of Psychiatry, University of Oviedo, c/ Julián Claveria s/n, 33006 Oviedo, Asturias, Spain.; Mental Health Services of the Principality of Asturias (SESPA), Plaza del Carbayón, 1, 33001 Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Av. Roma, s/n, 33011 Oviedo, Spain; Instituto de Neurociencias del Principado de Asturias (INEUROPA), Plaza Feijóo s/n, 33003 Oviedo, Spain.
¹⁰ Hospital Psiquiátrico de Álava, Araba kalea, 43, 01007, Vitoria-Gasteiz, Spain.
¹¹ Evolutive Biology, Ecology and Environmental Sciences Department, Faculty of Biology, University of Barcelona, Institute of Biomedicine of the University of Barcelona (IBUB), Avinguda Diagonal, 643, 08028 Barcelona, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain. Electronic address: barbara.arias@ub.edu.

PMID: 32553632
DOI: 10.1016/j.schres.2020.05.024

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Mental Disorders* / genetics
Nerve Tissue Proteins
Receptors, Nicotinic* / genetics
Smoking Cessation*

Substances

CHRNA5 protein, human
Nerve Tissue Proteins
Receptors, Nicotinic