Inhibition of the proliferative response of human B lymphocytes to B cell growth factor by transforming growth factor-beta

Eur J Immunol. 1988 Jan;18(1):111-6. doi: 10.1002/eji.1830180117.

Abstract

The effects of transforming growth factor-beta (TGF-beta) on the proliferative response of human B cells to the low molecular weight B cell growth factor (BCGF) have been investigated in this study. It was found that TGF-beta, at picomolar concentrations, strongly inhibited the BCGF-induced proliferation of anti-mu chain or Staphylococcus aureus Cowan I-activated human B cells and also of a BCGF-dependent cell line derived from a human lymphocytic nodular lymphoma. This inhibitory effect was detected in normal and serum-free culture conditions. The suppression was greatly reduced when TGF-beta was added to the culture one day after BCGF and could be reverted by removing TGF-beta from the culture medium. Since TGF-beta has been detected in supernatants from activated T cells, this factor may represent an important regulatory molecule in the feedback control of B cell activation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Anti-Idiotypic / physiology
  • B-Lymphocytes / drug effects*
  • B-Lymphocytes / immunology
  • Cell Division / drug effects
  • Cell Line
  • Drug Synergism
  • Humans
  • Immunoglobulin M / immunology
  • Immunoglobulin M / physiology
  • Immunosuppressive Agents / pharmacology*
  • Interleukin-4
  • Interleukins / pharmacology*
  • Leukemia, Hairy Cell / immunology
  • Leukemia, Hairy Cell / pathology
  • Lymphocyte Activation / drug effects*
  • Peptides / pharmacology*
  • Transforming Growth Factors
  • Tumor Cells, Cultured

Substances

  • Antibodies, Anti-Idiotypic
  • Immunoglobulin M
  • Immunosuppressive Agents
  • Interleukins
  • Peptides
  • anti-IgM
  • Interleukin-4
  • Transforming Growth Factors