Outcomes of Reflex Cryptococcal Antigen (CrAg) Screening in Human Immunodeficiency Virus (HIV)-Positive Patients With CD4 Counts of 100-200 Cells/µL in Botswana

Clin Infect Dis. 2021 May 4;72(9):1635-1638. doi: 10.1093/cid/ciaa899.

Abstract

Increasing the CD4-count threshold for cryptococcal antigen (CrAg) screening from ≤100 to ≤200 cells/µL resulted in a 3-fold increase in numbers screened. CrAg-prevalence was 3.5% at CD4 101-200 and 6.2% ≤100 cells/µL. Six-month mortality was 21.4% (9/42) in CrAg-positive CD4 ≤100 cells/µL and 3.2% (1/31) in CrAg-positive CD4 101-200 cells/µL.

Keywords: HIV treat all; HIV/AIDS; advanced HIV; antiretroviral therapy; cryptococcal antigen.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS-Related Opportunistic Infections* / diagnosis
  • AIDS-Related Opportunistic Infections* / epidemiology
  • Antigens, Fungal
  • Botswana / epidemiology
  • CD4 Lymphocyte Count
  • Cryptococcus*
  • HIV
  • HIV Infections* / complications
  • HIV Infections* / epidemiology
  • Humans
  • Mass Screening
  • Meningitis, Cryptococcal* / diagnosis
  • Meningitis, Cryptococcal* / epidemiology
  • Reflex

Substances

  • Antigens, Fungal