Enzymatic Quantification of Liver Lipids After Folch Extraction

Methods Mol Biol. 2020:2164:101-108. doi: 10.1007/978-1-0716-0704-6_11.

Abstract

The determination of the lipid content in liver offers the potential to investigate metabolic alterations in different research contexts. Here, we describe a method to determine cholesterol, triglycerides, and phospholipids in liver samples based on total lipid isolation by a 2:1 chloroform-methanol mixture (Folch extraction) and specific enzymatic colorimetric microassays in plate.

Keywords: Cholesterol; Enzymatic assay; Liver; Phospholipids; Triglycerides.

MeSH terms

  • Chloroform / chemistry
  • Cholesterol / metabolism
  • Colorimetry / methods*
  • Humans
  • Lipids / chemistry*
  • Liver / metabolism*
  • Methanol / chemistry
  • Phospholipids / metabolism
  • Solvents / chemistry
  • Triglycerides / metabolism

Substances

  • Lipids
  • Phospholipids
  • Solvents
  • Triglycerides
  • Chloroform
  • Cholesterol
  • Methanol