Impact of Coronary Atherosclerosis on Bioresorbable Vascular Scaffold Resorption and Vessel Wall Integration

JACC Basic Transl Sci. 2020 Jun 3;5(6):619-629. doi: 10.1016/j.jacbts.2020.04.005. eCollection 2020 Jun.

Abstract

The integration of the Absorb bioresorbable vascular scaffold (BVS) into the arterial wall has never been tested in an in vivo model of atherosclerosis. This study aimed to compare the long-term (up to 4 years) vascular healing responses of BVS to an everolimus-eluting metallic stent in the familial hypercholesterolemic swine model of atherosclerosis. The multimodality imaging and histology approaches indicate that the resorption and vascular integration profile of BVS is not affected by the presence of atherosclerosis. BVS demonstrated comparable long-term vascular healing and anti-restenotic efficacy to everolimus-eluting metallic stent but resulted in lower late lumen loss at 4 years.

Keywords: BVS, bioresorbable vascular scaffold; EES, everolimus-eluting stent; FHS, familial hypercholesterolemic swine; IVUS, intravascular ultrasonography; OCT, optical coherence tomography; bioresorbable vascular scaffolds; familial hypercholesterolemic swine; metallic drug-eluting stents; neoatherosclerosis.