The relationship between CD4+ follicular helper T cells and CD8+ resident memory T cells: sisters or distant cousins?

Changwei Peng; Stephen C Jameson

doi:10.1093/intimm/dxaa045

The relationship between CD4+ follicular helper T cells and CD8+ resident memory T cells: sisters or distant cousins?

Int Immunol. 2020 Sep 8;32(9):583-587. doi: 10.1093/intimm/dxaa045.

Authors

Changwei Peng^{1

2}, Stephen C Jameson^{1

2}

Affiliations

¹ Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
² Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.

Abstract

Independent studies over the last decade have characterized the properties of non-circulating CD8+ 'resident' memory T cells (TRM), which offer barrier protective immunity in non-lymphoid tissues and CD4+ follicular helper T cells (TFH), which mediate B-cell help in lymphoid sites. Despite their very different biological roles in the immune system, intriguing parallels have been noted between the trafficking properties and differentiation cues of these populations, parallels which have only sharpened with recent findings. In this review, we explore the features that underlie these similarities and discuss whether these indicate meaningful homologies in the development of CD8+ TRM and CD4+ TFH or reflect resemblances which are only 'skin-deep'.

Keywords: ICOS; KLF2; P2RX7; S1PR1.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
CD4-Positive T-Lymphocytes / immunology*
CD8-Positive T-Lymphocytes / immunology*
Humans

Abstract

Publication types

MeSH terms

Grants and funding