Young Onset Parkinson's Disease: A Modern and Tailored Approach

J Parkinsons Dis. 2020;10(s1):S29-S36. doi: 10.3233/JPD-202135.

Abstract

In people with young onset Parkinson's disease (YOPD), onset of symptoms is between 21 and 40 years of age. The distinction between YOPD and late-onset Parkinson's disease is supported by genetic differences (a genetic etiology is more common in people with YOPD) and clinical differences (e.g., dystonia and levodopa-induced dyskinesias are more common inYOPD). Moreover, people with YOPD tend to have different family and societal engagements compared to those with late-onset PD. These unique features have implications for clinical management, and call for a tailored multidisplinary approach involving shared-decision making.

Keywords: Parkinsons’s disease; caregiver; dystonia; genetics; quality of life; work; young-onset.

Publication types

  • Review

MeSH terms

  • Adult
  • Age of Onset
  • Disease Management*
  • Dystonia / epidemiology
  • Dystonia / psychology
  • Dystonia / therapy
  • Female
  • Humans
  • Male
  • Parkinson Disease / epidemiology*
  • Parkinson Disease / psychology
  • Parkinson Disease / therapy*
  • Pregnancy
  • Pregnancy Complications / epidemiology
  • Pregnancy Complications / psychology
  • Pregnancy Complications / therapy
  • Social Interaction*
  • Work Schedule Tolerance / physiology
  • Work Schedule Tolerance / psychology
  • Young Adult