COVID-19 has been prevalent in many countries and regions of the world since the end of December 2019. Studies have shown that SARS-CoV-2 infects the human body and replicates effectively through angiotensin-converting enzyme II (ACE2). ACE2 is widely distributed in various tissues and organs of the human body, such as intestinal epithelial cells, cardiomyocytes, renal tubular epithelial cells, and testicular stromal cells, etc. This could be one of the reasons for the diversity of clinical manifestations of COVID-19, or it may be the cause of accelerated disease progression and multi-system damage. This article reviews the clinical manifestations of COVID-19 related to the extrapulmonary system such as digestive, circulatory, urogenital, hematopoietic and nervous.
自2019年12月底以来，新型冠状病毒（2019-nCoV，SARS-CoV-2）感染的肺炎（COVID-19）已在全球多个国家和地区暴发流行。研究发现SARS-CoV-2通过血管紧张素转换酶II（ACE2）感染人体并进行有效复制。ACE2广泛分布于人体各个组织及器官，如肠道上皮细胞、心肌细胞、肾小管上皮细胞、睾丸间质细胞等。这可能是COVID-19临床表现多样化的原因之一，也可能是加速病情进展、造成多系统损害的原因。现就COVID-19相关的消化系统、循环系统、泌尿生殖系统、血液系统和神经系统等肺外临床表现进行综述。.
Keywords: COVID-19; Coronavirus; Manifestations.