Ex Vivo Analysis of a Porcine Bicuspid Aortic Valve and Aneurysm Disease Model

Ann Thorac Surg. 2021 Feb;111(2):e113-e115. doi: 10.1016/j.athoracsur.2020.05.086. Epub 2020 Jul 11.

Abstract

We identified an extremely rare congenital porcine type 0 lateral bicuspid aortic valve from a fresh porcine heart. Using a 3-dimensionally printed ex vivo left heart simulator, we analyzed valvular hemodynamics at baseline, in an aortic aneurysm disease model, and after valve-sparing root replacement. We showed that bicuspid aortic valve regurgitation due to aortic aneurysm can be successfully repaired without significant hemodynamic impairment using the valve-sparing root replacement technique in an individualized approach. Our results provide direct hemodynamic evidence supporting the use of valve-sparing root replacement for patients with bicuspid aortic valve regurgitation.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Video-Audio Media

MeSH terms

  • Animals
  • Aortic Aneurysm, Thoracic / complications*
  • Aortic Aneurysm, Thoracic / diagnosis
  • Aortic Aneurysm, Thoracic / surgery
  • Aortic Valve / diagnostic imaging*
  • Aortic Valve / surgery
  • Bicuspid Aortic Valve Disease / diagnosis*
  • Bicuspid Aortic Valve Disease / etiology
  • Bicuspid Aortic Valve Disease / surgery
  • Cardiac Surgical Procedures / methods*
  • Disease Models, Animal
  • Imaging, Three-Dimensional
  • Swine