Immunocyte single cell analysis of vaccine-induced narcolepsy

Eur J Immunol. 2021 Jan;51(1):247-249. doi: 10.1002/eji.202048633. Epub 2020 Jul 30.

Abstract

Increased incidence of narcolepsy type 1 (NT1) was observed following Pandemrix®-vaccination, initiated as a preventive measure against the 2009 Influenza pandemic. Here, single cell analysis was conducted to suggest a lower number of CD8+ CD27+ T cells among these patients. These findings provide understanding into the autoimmune pathogenesis of NT1.

Keywords: autoimmunity; mass cytometry; narcolepsy; single cell analysis; vaccine.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Basophils / immunology
  • CD8-Positive T-Lymphocytes / classification
  • CD8-Positive T-Lymphocytes / immunology
  • Case-Control Studies
  • Flow Cytometry
  • HLA-DQ beta-Chains / immunology
  • Humans
  • Influenza Vaccines / adverse effects*
  • Influenza Vaccines / immunology
  • Narcolepsy / etiology*
  • Narcolepsy / immunology*
  • Siblings
  • Single-Cell Analysis

Substances

  • HLA-DQ beta-Chains
  • HLA-DQB1 antigen
  • Influenza Vaccines
  • pandemrix

Supplementary concepts

  • Narcolepsy 1