A comparison of Triple I classification with neonatal early-onset sepsis calculator recommendations in neonates born to mothers with clinical chorioamnionitis

J Perinatol. 2020 Sep;40(9):1308-1314. doi: 10.1038/s41372-020-0727-9. Epub 2020 Jul 16.

Abstract

Objective: To compare the early-onset sepsis (EOS) calculator recommendations for infants born to mothers with clinical chorioamnionitis with those made by the Triple I classification.

Study design: Retrospective analysis of chorioamnionitis-exposed neonates ≥35 weeks. EOS risk was calculated with baseline risks of 0.5/1000 and 4/1000. Mothers were retrospectively categorized using the Triple I classification. Calculator recommendations were compared with the Triple I classification recommendations.

Results: We included 687 chorioamnionitis-exposed neonates. With a baseline risk of 0.5/1000, the calculator recommended no evaluation in 68.4% of infants of mothers with confirmed Triple I. With a baseline risk of 4/1000, 62.3% of infants of mothers with confirmed Triple I and 57.1% of infants born to mothers who did not meet fever criteria would have received evaluation.

Conclusions: The EOS calculator with either baseline risk does not recommend evaluation in a large number of infants born to mothers with confirmed Triple I.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Chorioamnionitis* / diagnosis
  • Chorioamnionitis* / drug therapy
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Mothers
  • Neonatal Sepsis* / diagnosis
  • Neonatal Sepsis* / drug therapy
  • Neonatal Sepsis* / epidemiology
  • Pregnancy
  • Retrospective Studies
  • Risk Assessment
  • Sepsis* / diagnosis
  • Sepsis* / drug therapy

Substances

  • Anti-Bacterial Agents