Establishing a Unified COVID-19 "Immunome": Integrating Coronavirus Pathogenesis and Host Immunopathology

Els Wauters; Karin Thevissen; Carine Wouters; Francesca Maria Bosisio; Frederik De Smet; Jan Gunst; Stephanie Humblet-Baron; Diether Lambrechts; Adrian Liston; Patrick Matthys; Johan Neyts; Paul Proost; Birgit Weynand; Joost Wauters; Sabine Tejpar; Abhishek D Garg

doi:10.3389/fimmu.2020.01642

Establishing a Unified COVID-19 "Immunome": Integrating Coronavirus Pathogenesis and Host Immunopathology

Front Immunol. 2020 Jul 3:11:1642. doi: 10.3389/fimmu.2020.01642. eCollection 2020.

Authors

Els Wauters¹, Karin Thevissen², Carine Wouters^{3

4}, Francesca Maria Bosisio⁵, Frederik De Smet⁶, Jan Gunst⁷, Stephanie Humblet-Baron⁸, Diether Lambrechts⁹, Adrian Liston¹⁰, Patrick Matthys¹¹, Johan Neyts¹², Paul Proost¹³, Birgit Weynand¹⁴, Joost Wauters¹⁵, Sabine Tejpar¹⁶, Abhishek D Garg¹⁷

Affiliations

¹ Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism and Department of Respiratory Diseases, University Hospitals KU Leuven, KU Leuven, Leuven, Belgium.
² Centre of Microbial and Plant Genetics (CMPG), KU Leuven, Leuven, Belgium.
³ Pediatric Immune-Inflammatory Diseases, Laboratory of Adaptive Immunology & Immunobiology, Department of Microbiology and Immunology, Department of Pediatrics, University Hospitals KU Leuven, KU Leuven, Leuven, Belgium.
⁴ Member of the European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases, Leuven, Belgium.
⁵ Laboratory for Translational Cell and Tissue Research, Department of Imaging and Pathology, Department of Pathology, University Hospitals of Leuven, KU Leuven, Leuven, Belgium.
⁶ The Laboratory for Precision Cancer Medicine, Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
⁷ Clinical Department and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
⁸ Laboratory of Adaptive Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
⁹ Laboratory for Translational Genetics, Department of Human Genetics, VIB Center for Cancer Biology, VIB and KU Leuven, Leuven, Belgium.
¹⁰ Department of Microbiology and Immunology, VIB Center for Brain and Disease Research, The Babraham Institute, Babraham Research Campus, KU Leuven, Cambridge, United Kingdom.
¹¹ Laboratory of Immunobiology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
¹² KU Leuven Department of Microbiology and Immunology, Rega Institute for Medical Research, Leuven, Belgium.
¹³ Laboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
¹⁴ Department of Pathology, University Hospitals KU Leuven, Leuven, Belgium.
¹⁵ Laboratory for Clinical Infectious and Inflammatory Diseases, Medical Intensive Care Unit, University Hospitals KU Leuven, KU Leuven, Leuven, Belgium.
¹⁶ Laboratory for Molecular Digestive Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.
¹⁷ Laboratory for Cell Stress & Immunity (CSI), Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.

No abstract available

Keywords: B-cells; SARS coronavirus; T-cell exhaustion; biomarkers; cytokine storm; interferons (IFNs); macrophages; neutrophils.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Betacoronavirus / physiology*
COVID-19
Coronavirus Infections / immunology*
Coronavirus Infections / pathology
Coronavirus Infections / therapy
Host-Parasite Interactions / immunology*
Humans
Pandemics
Pneumonia, Viral / immunology*
Pneumonia, Viral / pathology
Pneumonia, Viral / therapy
Respiratory Distress Syndrome / immunology*
Respiratory Distress Syndrome / pathology
Respiratory Distress Syndrome / therapy
Respiratory Distress Syndrome / virology
SARS-CoV-2