Long-term exposure to low levels of air pollution and mortality adjusting for road traffic noise: A Danish Nurse Cohort study

Abstract

Background: The association between air pollution and mortality is well established, yet some uncertainties remain: there are few studies that account for road traffic noise exposure or that consider in detail the shape of the exposure-response function for cause-specific mortality outcomes, especially at low-levels of exposure.

Objectives: We examined the association between long-term exposure to particulate matter [(PM) with a diameter of <2.5 µm (PM_2.5), <10 µm (PM₁₀)], and nitrogen dioxide (NO₂) and total and cause-specific mortality, accounting for road traffic noise.

Methods: We used data on 24,541 females (age > 44 years) from the Danish Nurse Cohort, who were recruited in 1993 or 1999, and linked to the Danish Causes of Death Register for follow-up on date of death and its cause, until the end of 2013. Annual mean concentrations of PM_2.5, PM_10, and NO₂ at the participants' residences since 1990 were estimated using the Danish DEHM/UBM/AirGIS dispersion model, and annual mean road traffic noise levels (L_den) were estimated using the Nord2000 model. We examined associations between the three-year running mean of PM_2.5, PM₁₀, and NO₂ with total and cause-specific mortality by using time-varying Cox Regression models, adjusting for individual characteristics and residential road traffic noise.

Results: During the study period, 3,708 nurses died: 843 from cardiovascular disease (CVD), 310 from respiratory disease (RD), and 64 from diabetes. In the fully adjusted models, including road traffic noise, we detected associations of three-year running mean of PM_2.5 with total (hazard ratio; 95% confidence interval: 1.06; 1.01-1.11), CVD (1.14; 1.03-1.26), and diabetes mortality (1.41; 1.05-1.90), per interquartile range of 4.39 μg/m³. In a subset of the cohort exposed to PM_2.5 < 20 µg/m³, we found even stronger association with total (1.19; 1.11-1.27), CVD (1.27; 1.01-1.46), RD (1.27; 1.00-1.60), and diabetes mortality (1.44; 0.83-2.48). We found similar associations with PM₁₀ and none with NO₂. All associations were robust to adjustment for road traffic noise.

Discussion: Long-term exposure to low-levels of PM_2.5 and PM₁₀ is associated with total mortality, and mortality from CVD, RD, and diabetes. Associations were even stronger at the PM_2.5 levels below EU limit values and were independent of road traffic noise.

Keywords: Air pollution; Cardiovascular disease; Danish Nurse Cohort; Diabetes; Mortality; Respiratory disease.