Multi-vendor multi-site T1ρ and T2 quantification of knee cartilage

J Kim; K Mamoto; R Lartey; K Xu; K Nakamura; W Shin; C S Winalski; N Obuchowski; M Tanaka; E Bahroos; T M Link; P A Hardy; Q Peng; R Reddy; A Botto-van Bemden; K Liu; R D Peters; C Wu; X Li

doi:10.1016/j.joca.2020.07.005

Multi-vendor multi-site T_1ρ and T₂ quantification of knee cartilage

Osteoarthritis Cartilage. 2020 Dec;28(12):1539-1550. doi: 10.1016/j.joca.2020.07.005. Epub 2020 Jul 30.

Authors

J Kim¹, K Mamoto², R Lartey³, K Xu⁴, K Nakamura⁵, W Shin⁶, C S Winalski⁷, N Obuchowski⁸, M Tanaka⁹, E Bahroos¹⁰, T M Link¹¹, P A Hardy¹², Q Peng¹³, R Reddy¹⁴, A Botto-van Bemden¹⁵, K Liu¹⁶, R D Peters¹⁷, C Wu¹⁸, X Li¹⁹

Affiliations

¹ Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA.
² Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA. Electronic address: mamoto7@hotmail.com.
³ Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA. Electronic address: LARTEYR@ccf.org.
⁴ Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA. Electronic address: kaipin_xu@163.com.
⁵ Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA. Electronic address: Nakamuk@ccf.org.
⁶ Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, OH, USA. Electronic address: wanyong.shin@gmail.com.
⁷ Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, OH, USA. Electronic address: winalsc@ccf.org.
⁸ Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, OH, USA. Electronic address: ObuchoN@ccf.org.
⁹ Department of Radiology and Biomedical Imaging, University of California, San Francisco (UCSF), CA, USA. Electronic address: Matthew.Tanaka@ucsf.edu.
¹⁰ Department of Radiology and Biomedical Imaging, University of California, San Francisco (UCSF), CA, USA. Electronic address: Emma.Bahroos@ucsf.edu.
¹¹ Department of Radiology and Biomedical Imaging, University of California, San Francisco (UCSF), CA, USA. Electronic address: Thomas.Link@ucsf.edu.
¹² Department of Radiology, University of Kentucky, Lexington KY, USA. Electronic address: Peter.Hardy@uky.edu.
¹³ Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA. Electronic address: dr.chrispeng@gmail.com.
¹⁴ Perelman School of Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: krr@pennmedicine.upenn.edu.
¹⁵ Arthritis Foundation, GA, USA. Electronic address: avanbemden@hotmail.com.
¹⁶ Siemens Medical Solution Inc, USA. Electronic address: Kecheng.liu@siemens-healthineeers.com.
¹⁷ GE Healthcare, Waukesha, WI, USA. Electronic address: Robert.Peters@med.ge.com.
¹⁸ Philips Healthcare, Andover, MA, USA. Electronic address: can.wu@philips.com.
¹⁹ Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, OH, USA. Electronic address: lix6@ccf.org.

Abstract

Objective: To develop 3D T_1ρ and T₂ imaging based on the same sequence structure on MR systems from multiple vendors, and to evaluate intra-site repeatability and inter-site inter-vendor reproducibility of T_1ρ and T₂ measurements of knee cartilage.

Methods: 3D magnetization-prepared angle-modulated partitioned k-space spoiled gradient echo snapshots (3D MAPSS) were implemented on MR systems from Siemens, GE and Philips. Phantom and human subject data were collected at four sites using 3T MR systems from the three vendors with harmonized protocols. Phantom data were collected by means of different positioning of the coil. Volunteers were scanned and rescanned after repositioning. Two traveling volunteers were scanned at all sites. Data were transferred to one site for centralized processing.

Results: Intra-site average coefficient of variations (CVs) ranged from 1.09% to 3.05% for T_1ρ and 1.78-3.30% for T₂ in phantoms, and 1.60-3.93% for T_1ρ and 1.44-4.08% for T₂ in volunteers. Inter-site average CVs were 5.23% and 6.45% for MAPSS T_1ρ and T₂, respectively in phantoms, and 8.14% and 10.06% for MAPSS T_1ρ and T₂, respectively, In volunteers.

Conclusion: This study showed promising results of multi-site, multi-vendor reproducibility of T_1ρ and T₂ values in knee cartilage. These quantitative measures may be applied in large-scale multi-site, multi-vendor trials with controlled sequence structure and scan parameters and centralized data processing.

Keywords: Cartilage imaging; Magnetic resonance imaging; Repeatability; Reproducibility; T(1ρ); T(2).

Publication types

Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Cartilage, Articular / diagnostic imaging*
Humans
Image Processing, Computer-Assisted
Knee Joint / diagnostic imaging*
Magnetic Resonance Imaging / methods*
Phantoms, Imaging
Reproducibility of Results

Abstract

Publication types

MeSH terms

Grants and funding