Abstract
In order to determine the presence of HLA antigens on human uveal melanomas, we tested anti-HLA monoclonal antibodies on tissue sections of these tumors. A great variety in expression of HLA class I and II antigens was present. A significantly lower expression of HLA class II antigens was present on uveal melanomas that had been irradiated before enucleation. These tumors lacked a lymphocytic infiltrate in comparison with nonirradiated tumors. These data suggest that radiotherapy affects expression of histocompatibility antigens on tumors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Antibodies, Monoclonal
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Female
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HLA Antigens / analysis
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HLA-D Antigens / analysis
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HLA-D Antigens / radiation effects*
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Humans
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Immunoenzyme Techniques
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Male
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Melanoma / immunology*
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Melanoma / pathology
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Melanoma / radiotherapy
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Middle Aged
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Uveal Neoplasms / immunology*
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Uveal Neoplasms / pathology
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Uveal Neoplasms / radiotherapy
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beta 2-Microglobulin / metabolism
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beta 2-Microglobulin / radiation effects
Substances
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Antibodies, Monoclonal
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HLA Antigens
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HLA-D Antigens
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beta 2-Microglobulin