Decreased expression of HLA class II antigens on human uveal melanoma cells after in vivo X-ray irradiation

Am J Ophthalmol. 1988 Jan 15;105(1):78-86. doi: 10.1016/0002-9394(88)90125-0.

Abstract

In order to determine the presence of HLA antigens on human uveal melanomas, we tested anti-HLA monoclonal antibodies on tissue sections of these tumors. A great variety in expression of HLA class I and II antigens was present. A significantly lower expression of HLA class II antigens was present on uveal melanomas that had been irradiated before enucleation. These tumors lacked a lymphocytic infiltrate in comparison with nonirradiated tumors. These data suggest that radiotherapy affects expression of histocompatibility antigens on tumors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antibodies, Monoclonal
  • Female
  • HLA Antigens / analysis
  • HLA-D Antigens / analysis
  • HLA-D Antigens / radiation effects*
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Melanoma / immunology*
  • Melanoma / pathology
  • Melanoma / radiotherapy
  • Middle Aged
  • Uveal Neoplasms / immunology*
  • Uveal Neoplasms / pathology
  • Uveal Neoplasms / radiotherapy
  • beta 2-Microglobulin / metabolism
  • beta 2-Microglobulin / radiation effects

Substances

  • Antibodies, Monoclonal
  • HLA Antigens
  • HLA-D Antigens
  • beta 2-Microglobulin