Galectin-3, N-terminal Propeptides of Type I and III Procollagen in Patients with Atrial Fibrillation and Metabolic Syndrome

Int J Mol Sci. 2020 Aug 8;21(16):5689. doi: 10.3390/ijms21165689.

Abstract

The aim of this study was to determine the concentration of galectin-3, PINP and PIIINP in patients with metabolic syndrome (MS) and atrial fibrillation (AF) with an assessment of the relationship with severity of left atrium fibrosis. A total of 480 subjects were included in the case-control study: MS patients (n = 337), 176 of whom had AF, 72 patients with AF without MS and 71 healthy subjects. Galectin-3, PINP and PIIINP blood concentrations and metabolic parameters were compared with the severity of left atrium fibrosis, measured by CARTO3. Galectin-3 in AF and MS patients is higher than in MS without AF and in healthy subjects (10.3 (4.8-15.4), 5.1 (4.3-8.8), 3.2 (2.4-4.2) ng/mL, p < 0.0001). Galectin-3 serum concentration in AF patients with MS is higher than in patients without MS: 10.3 (4.8-15.4), 6.8 (5.2-8.1) ng/mL, p = 0.0001. PINP and PIIINP concentration were higher in patients with AF and MS than in MS without AF: 3499.1 (2299.2-4567.3), 2130.9 (1425.3-2861.8) pg/mL, p < 0.0001, 94.9 (64.8-123.5), 57.6 (40.5-86.9) ng/mL, p < 0.0001. Galectin-3 correlates with PINP (r = 0.496, p < 0.001) and PIIINP concentration (r = 0.451, p < 0.0001). The correlation between galectin-3, PINP and the severity of left atrium fibrosis was found (r = 0.410, p < 0.001; r = 0.623, p < 0.001). Galectin-3 higher than 12.6 ng/mL increased the risk of AF more than five-fold. High galectin-3, PINP and PIIINP concentrations were associated with heart remodeling in MS patients and increased the risk of AF.

Keywords: PIIINP; PINP; atrial fibrillation; fibrosis; galectin-3; metabolic syndrome.

MeSH terms

  • Adult
  • Atrial Fibrillation / blood
  • Atrial Fibrillation / metabolism*
  • Biomarkers / blood
  • Female
  • Fibrosis
  • Galectin 3 / blood
  • Galectin 3 / metabolism*
  • Humans
  • Male
  • Metabolic Syndrome / blood
  • Metabolic Syndrome / metabolism*
  • Middle Aged
  • Peptide Fragments / blood
  • Peptide Fragments / metabolism*
  • Procollagen / blood
  • Procollagen / metabolism*
  • ROC Curve
  • Risk Factors

Substances

  • Biomarkers
  • Galectin 3
  • Peptide Fragments
  • Procollagen
  • procollagen Type I N-terminal peptide
  • procollagen Type III-N-terminal peptide