Evidence that leukocyte function-associated antigen-1 is involved in recirculation and homing of human lymphocytes via high endothelial venules

J Immunol. 1988 Mar 15;140(6):1851-3.

Abstract

We report the results of mAb inhibition studies of human lymphocyte-high endothelial venule interaction in vitro. These studies in which T cells from both normal donors and from a LFA-1-deficient patient were used indicate that in addition to a system of organ-specific 90-kDa "homing" receptors on lymphocytes, LFA-1 is also involved in lymphocyte recirculation and homing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Monoclonal / immunology
  • Antigens, Surface / deficiency
  • Antigens, Surface / immunology
  • Antigens, Surface / physiology*
  • Cell Adhesion
  • Cell Movement*
  • Humans
  • Infant, Newborn
  • Lymphocyte Function-Associated Antigen-1
  • Organ Specificity
  • T-Lymphocytes / physiology*
  • Venules

Substances

  • Antibodies, Monoclonal
  • Antigens, Surface
  • Lymphocyte Function-Associated Antigen-1