Severe adenovirus pneumonia with hemophagocytic syndrome and respiratory failure

Arch Pediatr. 2020 Oct;27(7):383-385. doi: 10.1016/j.arcped.2020.07.003. Epub 2020 Aug 15.

Abstract

We report the case of an 18-month-old infant with severe serotype 3 adenovirus pneumonia, exceptionally associated with hemophagocytic syndrome. Treatment included cidofovir and mechanical ventilation for 13 days. The child developed chronic respiratory insufficiency due to bronchiectasis and bronchiolitis obliterans.

Keywords: Adenovirus; Bronchiectasis; Bronchiolitis obliterans; Chronic respiratory failure; Cidofovir.

Publication types

  • Case Reports

MeSH terms

  • Adenovirus Infections, Human / complications
  • Adenovirus Infections, Human / diagnosis*
  • Adenovirus Infections, Human / therapy
  • Antiviral Agents / therapeutic use
  • Bronchiectasis / diagnosis
  • Bronchiectasis / therapy
  • Bronchiectasis / virology*
  • Bronchiolitis Obliterans / diagnosis
  • Bronchiolitis Obliterans / therapy
  • Bronchiolitis Obliterans / virology*
  • Chronic Disease
  • Cidofovir / therapeutic use
  • Combined Modality Therapy
  • Humans
  • Infant
  • Lymphohistiocytosis, Hemophagocytic / diagnosis
  • Lymphohistiocytosis, Hemophagocytic / therapy
  • Lymphohistiocytosis, Hemophagocytic / virology*
  • Pneumonia, Viral / complications
  • Pneumonia, Viral / diagnosis*
  • Pneumonia, Viral / therapy
  • Respiration, Artificial
  • Respiratory Insufficiency / diagnosis
  • Respiratory Insufficiency / therapy
  • Respiratory Insufficiency / virology*
  • Severity of Illness Index

Substances

  • Antiviral Agents
  • Cidofovir